Pinealon Research Compound — EDR Pineal Gland Peptide Bioregulator

Pinealon (CAS 155321-98-7, MW 363.33 Da, C₁₂H₂₁N₅O₇) is the tripeptide Glu-Asp-Arg (EDR in single-letter code), the pineal gland-derived cytomedine from the Khavinson peptide bioregulator series. The cytomedine concept, developed by Vladimir Khavinson and colleagues over four decades of research, proposes that short oligopeptides (2-4 amino acids) derived from specific tissues carry tissue-specific epigenetic regulatory information — influencing gene expression in corresponding cell types when administered in research models. Pinealon's sequence (EDR) was derived from the peptide fraction of bovine pineal gland extracts through biochemical fractionation and characterization. The broader Khavinson peptide series includes: Epitalon (AEDG, pineal/aging regulation — distinct from Pinealon), Selank (TKPRP, tuftsin-derived), and numerous other tissue-specific bioregulators; Pinealon (EDR) is specifically associated with the pineal gland and neural-retinal tissue.

Research interest in Pinealon spans several areas. In neuroprotection models, the EDR sequence has been studied in retinal cell cultures and neural systems for potential pro-survival signaling; several publications from the Khavinson research group report effects on oxidative stress markers, cytochrome c oxidase activity, and neuronal survival in vitro. In circadian and aging biology, the pineal gland's role in melatonin synthesis and circadian rhythm regulation provides the mechanistic rationale — Pinealon research has examined whether short peptide bioregulators can influence pineal cell function, AANAT (arylalkylamine N-acetyltransferase) activity, and melatonin output in preclinical models. Epigenetic regulation is another focus: Khavinson papers report that short peptides including EDR interact with gene promoter sequences (a DNA-binding model of action), potentially modulating expression of aging-associated genes such as PCNA (proliferating cell nuclear antigen) and p53 family members. These findings come primarily from in-vitro cell-culture and animal models.

As a research reagent, Pinealon (EDR) is used in studies of pineal gland biology, retinal neuroprotection, circadian regulation, aging models, and short peptide epigenetic mechanisms. DMV Research supplies Pinealon as a lyophilized compound with per-batch Certificate of Analysis confirming identity by mass spectrometry and purity ≥99% by HPLC.