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DMV Research Ipamorelin research peptide vial
peptides

Ipamorelin

Selective growth hormone secretagogue for GH research.

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For in-vitro and pre-clinical research use only. Not for human consumption, therapeutic use, or veterinary application. Research Use Only Policy

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Compound Information

Updated 2026-06-08

Technical specifications

A selective ghrelin-receptor (GHS-R1a) agonist and pentapeptide growth-hormone secretagogue. Distinguished in research for its selectivity profile — minimal cortisol or prolactin response compared to other secretagogues.

Molecular Profile

What Is Ipamorelin?

Type
Synthetic Pentapeptide (GHS-R1a Agonist)
CAS Number
170851-70-4
Molecular Weight
711.9 g/mol
Molecular Formula
C₃₈H₄₉N₉O₅
Amino Acids
5
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Primary Target
GHS-R1a (ghrelin receptor)
Storage Requirements

Stability Information

Avoid freeze/thaw cyclesProtect from lightKeep refrigerated

Lyophilized (powder)

-20°C· stable

Reconstituted

2–8°C· use within 30 days

Mechanism

GHS-R1a Selective Agonism

GH secretagogue without ACTH/cortisol response

IpamorelinPentapeptideGHS-R1aGhrelin receptorGH pulsePituitary releaseEnteric NSGI motility

Research Outcomes

↑ GH secretionNo ACTH/cortisol spike
↑ IGF-1Anabolic signaling
↑ GI motilityProkinetic activity
Clinical Research

Dosing in Clinical Studies

Protocols from published peer-reviewed trials. Provided for educational reference only — not prescribing guidance.

ProtocolDoseRouteFrequencyIndication (Research)
Phase 2 Postoperative Ileus Trial (Beck et al.)0.01 mg/kgIntravenous (IV) infusionThree times daily (TID) starting 3–6 hours post-surgeryPostoperative GI motility research model

Sources & References

8 sources · research references

Peer-Reviewed

European Journal of Endocrinology

Ipamorelin, the First Selective Growth Hormone Secretagogue

1998

Raun K, et al.

Peer-Reviewed

British Journal of Pharmacology

Pharmacokinetic and Pharmacodynamic Study of Ipamorelin: A New Growth Hormone Releasing Peptide

1999

Johansen PB, Segev Y, Landau D, et al.

Peer-Reviewed

Growth Hormone & IGF Research

The Growth Hormone Secretagogue Ipamorelin Counteracts Glucocorticoid-Induced Decrease in Bone Formation

2001

Andersen NB, et al.

Peer-Reviewed

Journal of Gastrointestinal Surgery

Ipamorelin Reduces Postoperative Ileus in Gastrointestinal Surgery: A Phase 2 Randomized Controlled Trial

2014

Beck DE, Sweeney WB, McCarter MD

Peer-Reviewed

Journal of Pharmacology and Experimental Therapeutics

Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus

2009

Venkova K, et al.

Review

Sexual Medicine Reviews

The Safety and Efficacy of Growth Hormone Secretagogues

2018

Sigalos JT, Pastuszak AW

Peer-Reviewed

Physiology & Behavior

GHS-R1a Agonists Anamorelin and Ipamorelin Inhibit Cisplatin-Induced Weight Loss in Ferrets

2024

Lu Z, et al.

Database

PubChem Database

Ipamorelin Compound Information

Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations. See our Research Use Only policy.

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