Semax
Synthetic ACTH analog for nootropic and neuroprotective research.
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For in-vitro and pre-clinical research use only. Not for human consumption, therapeutic use, or veterinary application. Research Use Only Policy
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Compound Information
Updated 2026-06-08Technical specifications
A synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-7) with a Pro-Gly-Pro C-terminal extension. Studied in neurochemistry research for effects on BDNF expression and dopaminergic systems.
What Is Semax?
- Type
- Synthetic Heptapeptide (ACTH Analog)
- CAS Number
- 80714-61-0
- Molecular Weight
- 813.9 g/mol
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- Amino Acids
- 7
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Primary Target
- BDNF/TrkB pathway, melanocortin receptors, dopaminergic system
Stability Information
Lyophilized (powder)
-20°C· stable
Reconstituted
2–8°C· use within 30 days
Neurotrophic Signaling
BDNF/TrkB pathway modulation
Research Outcomes
Sources & References
7 sources · research references
Brain Research
Semax Regulates BDNF and trkB Expression in the Rat Hippocampus
2006
Dolotov OV, et al.
BMC Genomics
Gene Expression Profile of Semax Action on the Hippocampus of Rat Brain
2014
Medvedeva EV, et al.
Molecular Genetics and Genomics
Semax, an Analog of ACTH(4-7), Regulates Expression of Immune Response Genes During Ischemic Brain Injury
2017
Medvedeva EV, et al.
Journal of Molecular Neuroscience
Effects of Semax on the Expression of Genes Related to the Neurotrophin Signaling Pathway in Rat Basal Ganglia
2010
Shadrina M, et al.
Genes
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion
2020
Filippenkov IB, et al.
Neurochemical Research
Semax Activates Dopaminergic and Serotoninergic Brain Systems in Rodents
2005
Eremin KO, et al.
PubChem Database
Semax Compound Information
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations. See our Research Use Only policy.
