MOTS-C
Mitochondrial-derived peptide for metabolic and exercise research.
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For in-vitro and pre-clinical research use only. Not for human consumption, therapeutic use, or veterinary application. Research Use Only Policy
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Compound Information
Updated 2026-06-08Technical specifications
A 16-amino-acid mitochondrially-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. One of several MDPs studied as metabolic-signaling molecules with AMPK-pathway activity in cellular-biology research.
What Is MOTS-C?
- Type
- Mitochondrially-Derived Peptide
- CAS Number
- 1627580-64-6
- Molecular Weight
- 2,174.6 g/mol
- Molecular Formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Amino Acids
- 16
- Sequence
- MRWQEMGYIFYPRKLR
- Primary Target
- AMPK, FOXO1, ARE (antioxidant response element)
Stability Information
Lyophilized (powder)
-20°C· stable
Reconstituted
2–8°C· use within 30 days
AMPK Activation Pathway
Exercise-mimetic mitochondrial signaling
Research Outcomes
Dosing in Clinical Studies
Protocols from published peer-reviewed trials. Provided for educational reference only — not prescribing guidance.
| Protocol | Dose | Route | Frequency | Indication (Research) |
|---|---|---|---|---|
| CB4211 Phase 1b/2a (NAFLD/Obesity) | 0.5 mg/kg or 1.0 mg/kg | Subcutaneous injection | Once daily for 12 weeks | NAFLD and obesity research model |
Sources & References
9 sources · research references
Cell Metabolism
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
2015
Lee C, Zeng J, Drew BG, et al.
Aging Cell
Mitochondrial Genotype Associated with Exceptional Longevity in MOTS-c Coding Region
2015
Fuku N, Pareja-Galeano H, Zempo H, et al.
Nature Communications
MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
2021
Reynolds JC, et al.
Pediatric Diabetes
Circulating MOTS-c Levels Are Decreased in Obese Male Children and Adolescents
2018
Du C, Zhang C, Wu W, et al.
Frontiers in Endocrinology
MOTS-c: A Promising Mitochondrial-Derived Peptide for Therapeutic Exploitation
2023
Zheng Y, Wei Z, Wang T
Diabetes and Metabolism Journal
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
2022
Yoon TK, Lee CH, Kwon O, Kim MS
Journal of Translational Medicine
Mitochondria-Derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging
2023
Wan W, et al.
ClinicalTrials.gov
Study of CB4211 in NAFLD and Obesity (CohBar Inc., Phase 1b/2a)
2019
PubChem Database
MOTS-C Compound Information
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations. See our Research Use Only policy.
